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EPA/600/BP-92/001a,b,c

August 1994

External Review Draft

Health Assessment Document for 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and Related Compounds Volume III of III

TABLE OF CONTENTS - OVERVIEW

Volume I

1.0. DISPOSITION AND PHARMACOKINETICS
2.0. MECHANISM(S) OF ACTION
3.0. ACUTE, SUBCHRONIC, AND CHRONIC TOXICITY
4.0. IMMUNOTOXICITY
5.0. DEVELOPMENTAL AND REPRODUCTIVE TOXICITY
6.0. CARCINOGENICITY OF TCDD IN ANIMALS

Volume II

7.0. EPIDEMIOLOGY/HUMAN DATA / PART A: CANCER EFFECTS

7.0. EPIDEMIOLOGY/HUMAN DATA / PART B: EFFECTS OTHER THAN CANCER

8. DOSE-RESPONSE MODELING

Volume III

9. RISK CHARACTERIZATION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) AND RELATED COMPOUNDS

APPENDIX A: A Mechanistic Model of Effects of Dioxin on Gene Expression in the Rat Liver A-l

APPENDIX B: Modeling Receptor-Mediated Processes with Dioxin: Implications for Pharmacokinetics and Risk Assessment B-l

APPENDIX C: Parameters for Analyzing Preneoplastic Lesions and Tumor Incidence in Rat Hepatocytes C-l

APPENDIX D: Considerations for Using Dose Surrogates in Estimating Tumor Incidence D-l

APPENDIX E: Tetrachlorodibenzo-p-Dioxin Empirical Relationships for Non-Cancer End Points E-l